Female mice showed changes similar to those of male mice, with no significant differences in BW, tissue weight, or tibial length between WT and L973F-IR mice (Supplemental Figure 10, A–D), but a significant increase in total body length in L973F-IR mice compared with controls (Supplemental Figure 10E), mild glucose intolerance (Supplemental Figure 10F), and significantly impaired insulin sensitivity, as assessed by ITT (Supplemental Figure 10, G and H). The gene discussed is INS; the disease is Glucose intolerance.