We then used a gene expression profiling dynamic analysis database (Gene Expression Profiling Interactive Analysis, GEPIA) (45) to determine the expression levels of UBE2C and UBE2S between non–small cell lung cancer (NSCLC) and normal lung tissues, and found that both genes are overexpressed in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) tissues (Supplemental Figure 1B). Here, UBE2S is linked to squamous cell lung carcinoma.