H&E staining analysis revealed that while mice with Ube2c deletion alone [Kras(–)Ube2c–/–] had normal lung development without any tumor formation (Figure 2B and Supplemental Figure 2C), the WT mice [Kras(+)Ube2c+/+ or Kras(+)Ube2c+/–] developed, as expected, multiple lung adenomas with few adenocarcinomas (Figure 2B and Supplemental Figure 2C). Here, KRAS is linked to adenocarcinoma.