DEPTOR and neoplasm: However, 2 in vivo studies, using genetically modified Deptor-knockout (Deptor-KO) mouse models, showed that Deptor is a tumor suppressor, whose depletion (a) promoted lung tumorigenesis induced by the combination of KrasG12D activation and p53 deletion via the activation of EGFR/mTORC signaling (26), and (b) accelerated prostate tumorigenesis triggered by Pten loss via the activation of mTORC signaling (24).