On the other hand, unlike UBE2C knockdown, UBE2S knockdown had no effect on MAPK and mTORC signaling in A427 cells, whereas inactivated mTORC appeared to be independent of DEPTOR in H1792 cells (Supplemental Figure 3D), largely consistent with its lack of effect on the growth of lung cancer cells upon depletion (Supplemental Figure 1, E and F). Here, UBE2C is linked to lung carcinoma.