mTORC signals are negative regulators of autophagy (51), and UBE2C-mediated autophagy repression contributes to malignant phenotypes of lung cancer cells (19), suggesting that autophagy modulation via the DEPTOR/mTORC axis could be actively involved in the growth-suppressing effect of UBE2C knockdown as well. The gene discussed is DEPTOR; the disease is lung cancer.