In multiple lung cancer cell lines, knockdown of either UBE2C or CDH1 significantly extended the protein half-life of DEPTOR (Figure 5, A and B, and Supplemental Figure 5, B and C), while ectopic overexpression of UBE2C or CDH1 shortened the protein half-life of DEPTOR (Figure 5, C and D, and Supplemental Figure 5, D and E). Here, UBE2C is linked to lung cancer.