Although previous studies, using in vitro cell culture settings, have shown the growth-promoting and autophagy-suppressing effects of UBE2C in lung cancer cells (19, 52), to the best of our knowledge no in vivo study using a Ube2c conditional KO mouse model has been conducted to understand the role of UBE2C during lung tumorigenesis. This evidence concerns the gene UBE2C and lung carcinoma.