SHC4-6 dose-dependently lowered ROS levels in Fine Dust-induced HaCaT keratinocytes, also downregulated inflammatory cytokines, tumour necrosis factor-α, interleukin (IL)-1β, -5, -6, -8, -13, interferon-γ, and chemokines, macrophage-derived chemokine, eotoxin, and thymus and activation regulated chemokine. Molecular mediators of MAPK and NF-κB pathway were downregulated by SHC4-6. This could successfully recover the impact of FD on skin barrier molecular mediators. The gene discussed is NFKB1; the disease is Fabry disease.