TYR and melanoma: Further research found that 974-A, phlorofucofuroeckol-A and eckol, isolated from Ecklonia stolonifera Okamura, reduced the cellular melanin content and tyrosinase activity, and downregulated the expression of melanogenesis enzymes including tyrosinase, tyrosinase-related protein (TRP)-1 and TRP-2 in B16F10 melanoma cells [81].