Indeed, in other conditions of brain dysfunction such as early Alzheimer’s disease [9]) and convulsions-induced neurodegeneration [30], we have also reported an early upregulation of the pathway released ATP-CD73 density and activity-A2AR density and function controlling the early abnormally increased plasticity of hippocampal LTP that pre-dated the onset of synaptotoxicity and memory symptoms [9, 30]. The gene discussed is NT5E; the disease is early-onset autosomal dominant Alzheimer disease.