The pathways identified included gap junctions, signaling pathways regulating the pluripotency of stem cells, transforming growth factor (TGF)-β signaling, γ-aminobutyric acid (GABA)-ergic synapse, axon guidance, glioma, Wnt signaling, thyroid hormone signaling, toll-like receptor signaling, vascular endothelial growth factor (VEGF) signaling, Notch signaling, mammalian target of rapamycin (mTOR) signaling, Alzheimer’s disease, neurotrophin signaling, and glutamatergic synapse. This evidence concerns the gene TGFB1 and early-onset autosomal dominant Alzheimer disease.