We defined an elevation in ALT ≥ 2–5 times the ULN as acute non-severe HEV infection, an elevation in ALT > 5 times the ULN as acute severe HEV infection, and liver dysfunction as clinical or laboratory signs of 1) coagulopathy, 2) jaundice, or 3) hepatic encephalopathy. This evidence concerns the gene GPT and blood coagulation disease.