MGMT and neoplasm: In more detail, the implemented solution consists of three main blocks, as summarized in Figure 1: the Data Preparation step, generating isotropic and normalized acquisitions; the Knowledge-Based Filtering (KBF), leveraging the medical knowledge to pre-select, in an unsupervised manner, the Region of Interest (ROI) corresponding to possibly tumor regions in the MRI scans; the MGMT promoter methylation identification, using a 2D or 3D CNN for the identification of a methylation process.