OCRL and oculocerebrorenal syndrome: Genetic analyses showed that Lowe syndrome-associated mutations are mostly in exons 8–23 (5-phosphatase, ASH, and RhoGAP domains), whereas Dent-2-associated mutations are typically in exons 1-7 (PH domain) (Table 1) [101,104], suggesting that the distinct symptoms in these two disorders result from different mutations.