Enrichment analysis showed that the common genes mainly played a role in TGF-β, fibrillar collagen, NADPH oxidase activity, and multiple hormone-related signaling pathways, which suggested that metabolic disorders, oxidative stress, and myocardial fibrosis might play a role in the obesity-induced development of DCM. The gene discussed is FMO5; the disease is familial dilated cardiomyopathy.