According to Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, the terms mainly enriched were the AGE-RAGE signaling pathway in diabetic complications, cGMP-PKG, cAMP and PI3K-Akt signaling pathways, human papillomavirus infection, regulation of lipolysis in adipocytes, and multiple hormone (relaxin, aldosterone, vasopressin, adrenergic, thyroid hormone, insulin, glucagon)-related signaling pathways (Figure 2D). Here, INS is linked to human papilloma virus infection.