Given that COL1A2, closely related to CCDC80, mediates the production of fibrillar collagen, we may assume that the combined action of CCDC80 and COL1A2 promotes myocardial fibrosis and accelerates the development of cardiomyopathy in the presence of obesity risk factors. Here, CCDC80 is linked to obesity due to melanocortin 4 receptor deficiency.