Enrichment analysis showed that the common genes mainly played a role in TGF-β, fibrillar collagen, NADPH oxidase activity, and multiple hormone-related signaling pathways, which suggested that metabolic disorders, oxidative stress, and myocardial fibrosis might play a role in the obesity-induced development of DCM. This evidence concerns the gene TGFB1 and familial dilated cardiomyopathy.