For example, while cTnT, hs-cTnT, BNP, NT-proBNP, and D-dimers levels are influenced by physical activity, this can actually interfere with their interpretation in an emergency setting when a diagnosis of an acute coronary syndrome, pulmonary embolism, or acute heart failure is suspected, as shown by a meta-analysis published in 2015 by Sedaghat-Hamedani et al. and supported by a previous study conducted by Smith et al. in 2004 [106,107]. This evidence concerns the gene NPPB and acute coronary syndrome.