Ceramide produced by metabolic disorders activates protein kinase B (Akt, or PKB) and pro-apoptotic signals, which in turn leads to impaired AKT-stimulated glucose transporter protein ectopic in the cell membrane, thereby inhibiting glucose uptake and glycogen synthesis, and leading to the development and progression of insulin resistance and type 2 diabetes [16]. The gene discussed is AKT1; the disease is type 2 diabetes mellitus.