S1PR3 and ischemia: CYM-51736 is an S1P3R-specific agonist; using an in vitro ischemia/reperfusion injury heart model, researchers found that myocardial injury caused by ischemia/reperfusion was ameliorated by the specific activation of S1P3, and concluded that specific drug targeting of the S1P3 receptor could provide therapeutic benefit in ischemic heart disease without the adverse effects of overall activation of other cardiac S1P receptors [139].