HMGCR and metabolic dysfunction-associated steatotic liver disease: Statins, which limit cholesterol biosynthesis through inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase, have been shown to improve steatosis and NAFLD activity scores across multiple small studies, although robust, high-quality evidence is lacking, which limits their indication in managing liver disease in NAFLD [292,293,294,295,296,297].