SPP1 and myocardial infarction: Our results show that, 7d after myocardial infarction, the expression levels of Timp1, Sparc, Spp1, Tgfb1, Vim, and Serpina3n were significantly increased in fibroblasts, and in macrophages, the expression levels of Timp1, Spp1, Tgfb1, and Vim were significantly increased; in contrast, Sparc, Serpine1, Serpina3n, and Thbs2 were significantly down-regulated.