On the other hand, Col4a1, Col4a3, Col4a5, Col5a3, Col11a2, Col14a1, Col15a1, Col16a1, and Col22a1 were found in normal ECM but not in tumor ECM; Col25a1 was found only in tumor ECM but not in normal ECM. The gene discussed is COL22A1; the disease is neoplasm.