Such terms include Positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway and Positive regulation of protein phosphorylation perhaps related to altered phosphorylation, that is well described in HD (38–42), Additionally, this analysis identified terms associated with autophagic balance (Regulation of cellular protein metabolic process and Regulation of proteolysis), a process deeply engrained in HD pathophysiology (43). Here, MARK2 is linked to Huntington disease.