Although we saw evidence of frequent silencing of these T-box genes in cancer cell lines by both polycomb-repressed chromatin (H3K27me3) and DNA hypermethylation (Figure S6 and data not shown [23]), one cancer cell line, U87 astrocytoma cells, expressed TBX15 at moderate levels [38]. Here, TBX15 is linked to astrocytoma (excluding glioblastoma).