Consistent with this notion, alterations in the expression of MBD5 gene causes a rare NDD termed MBD5-associated neurodevelopmental disorder (MAND), a general term that encompases 2q23.1 deletion syndrome, 2q23.1 duplication syndrome and MBD5 heterozygous variants (reviewed in [173]). The gene discussed is MBD5; the disease is neurodevelopmental disorder.