Surprisingly, a triple HBV/HCV/HIV infection was reported in two male patients (7.1%), both negative for HBeAg, undetectable HBV-DNA load and <2000 IU/mL for HCV-RNA (genotype 1B and 1A), undergoing treatment (one with tenofovir associated with lamivudine in combined therapy and the other, lamivudine monotherapy); one presenting normal ALT and the other, altered ALT. The gene discussed is GPT; the disease is HIV infectious disease.