Since angiotensin II levels in circulation directly affect vascular pressure by influencing the adrenal glands to produce aldosterone and via its breakdown products (Angiotensin 1 to 7) [15], it is also postulated that the renin–angiotensin–aldosterone system (RAAS) may play a pivotal role in COVID-19, which can possibly affect thrombosis based on the mechanisms discussed above (Figure 1). Here, REN is linked to COVID-19.