The usual panel performed are the cytokeratins: CK7, CK20 (to determine glandular epithelium), SOX10 (for melanoma, neural, and myoepithelial tumors), and p63 (negative staining is helpful to rule out primary cutaneous carcinoma, and positive staining rules in squamous cell carcinoma and other primary adnexal carcinomas) [21]. The gene discussed is SOX10; the disease is squamous cell carcinoma.