This review focuses on the significance of Sialyltransferase and Neuraminidase in cancer prognosis and has highlighted the various Sialyltransferase and Neuraminidase families, such as ST3GAL, ST6GAL, ST6GALNAC, ST8SIA, NEU, involved in the metastasis of various cancers such as breast, pancreatic, ovarian, head and neck, etc. The compilation of experimental and computational data presented in this paper provides researchers working on particular cancers with possible ST/NEU targets or biomarkers for further studies. This evidence concerns the gene NEU1 and cancer.