mRNA expression analysis of various sialyltransferases and neuraminidases was conducted using RT-qPCR in Oral Squamous Cell Carcinoma (OSCC), found sialyltransferases ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL6, and ST6GAL1 and neuraminidase NEU3 to be downregulated in tumor tissues in comparison to normal. The gene discussed is ST3GAL4; the disease is neoplasm.