ZNF540 and head and neck squamous cell carcinoma: First of all, our results from the GSE65858 dataset confirmed the upregulation of ZNF540 expression in the case of HPV(+) compared to HPV(−) HNSCC samples (6.51 ± 0.021 vs. 6.43 ± 0.009; p = 0.0002) (Figure 6B).