TP53 and plasma cell myeloma: Most importantly, super-enhancers, as well as genes, identified in several steps of molecular pathways, such as NF-kB pathway, p53 signaling, mTOR signaling, cancer stem cell pathway, and NOTCH pathway, in myeloma maintain the crosstalk within the myeloma microenvironment, resulting in the activation of chromatin regulatory network in myeloma [14].