Chromatin remodeling and histone rearrangement is characterized by popular chromatin remodelers, such as ARID family proteins (ARID1A, ARID1B, and ARID2) [11], and several important proteins, such as DNA methyl transferases, DNMT1 and DNMT3A; histone-modifying enzymes, such as HAT1, KMT2C, etc. [12], have a deep impact in the organization of myeloma genome, and aberration in any of these factors leads to change in clonal propagation of myeloma cells. This evidence concerns the gene DNMT3A and plasma cell myeloma.