Chromatin remodeling and histone rearrangement is characterized by popular chromatin remodelers, such as ARID family proteins (ARID1A, ARID1B, and ARID2) [11], and several important proteins, such as DNA methyl transferases, DNMT1 and DNMT3A; histone-modifying enzymes, such as HAT1, KMT2C, etc. [12], have a deep impact in the organization of myeloma genome, and aberration in any of these factors leads to change in clonal propagation of myeloma cells. The gene discussed is KMT2C; the disease is plasma cell myeloma.