Overexpression of c-erbB-2 was found in 3/31 cases (9.7%) and 13 patients (13/31 = 41.9%) had a high Ki-67 expression (≥20%), significantly higher in the SF compared to the RB group (10/18 = 55.5% vs. 3/12 = 25%; p < 0.001). This evidence concerns the gene MKI67 and retinoblastoma.