Risk-based breast cancer screening studies, such as BREATHE, predicts breast cancer risk based on both high-risk breast cancer genes (ATM, BRCA1, BRCA2, CHEK2, PALB2, BARD1, RAD51C, RAD51D, or TP53) and common-variant-based breast cancer polygenic risk scores [17,65,66]. The gene discussed is PALB2; the disease is breast cancer.