Clinical manifestations of this tumor range from the incidental finding of mucocele treated with appendectomy to well-established disease with disseminated mucin throughout the peritoneal cavity resulting in pseudomyxoma peritonei (PMP), a progressive and fatal peritoneal surface malignancy [1,2] which requires treatment with cytoreductive surgery (CRS) in combination with hyperthermic intraperitoneal chemotherapy (HIPEC) [3,4,5,6]. This evidence concerns the gene MUC5AC and neoplasm.