The analysis of BiP expression in normal and cancer tissues showed that BiP mRNA levels are higher in breast cancer tissues vs. normal tissues [non-paired, p = 9.13 × 10−84 or paired adjacent tissue, p = 5.96 × 10−14] and highest in the metastases (non-paired tissues, p = 2.33 × 10−90; Figure 1A). This evidence concerns the gene HSPA5 and cancer.