Instead, the strengths are represented by the study of an extremely heterogeneous tumor (glioblastoma IDH-wild type), with few identified prognostic factors in a clinical-imaging-morphogenetic manner that can be the basis of future studies on larger groups in order to the identification of some infallible prognostic factors as was achieved in the case of astrocytoma grade 4 IDH-mutant. The gene discussed is IDH1; the disease is astrocytoma (excluding glioblastoma).