APOE and Alzheimer disease: Moreover, phospholipase D3 (PLD3), bridging integrator 1 (BIN1), phosphatidylinositol-binding clathrin assembly protein (PICALM) [26], and sortilin-related receptor (SORL1)—the next strongest genetic risk factors of AD after APOE4 and TREM2—were also involved in regulating the endocytosis process [27,28].