Although GRP78 is an important heat shock protein to facilitate cancer cell adaptation to the stress environment [1], the exosome experiments with no significant differences between GRP78-KD and mock groups in AKT phosphorylation suggest that some other proteins may be involved in the activation of the AKT signaling pathway, upregulating p-AKT in the GRP78-KD cells. The gene discussed is AKT1; the disease is cancer.