Given that the nuclear accumulation of FOXO3a induced by the API-2 treatment induces the cell migration of CRC cells containing high nuclear β-catenin [17,19], we evaluated the inhibition effects of KY1022 on the cell migration using a wound-healing assay and investigated the actin rearrangement of the migratory LoVo cells derived from metastatic tumor nodules. The gene discussed is FOXO3; the disease is neoplasm.