Unexpectedly, CRC patients with a high expression of FOXO3a, known as an apoptosis-inducing gene, showed low OS, DFS, and DSS (Figure 1B), similar to oncogenes, such as CTNNB1, suggesting that FOXO3a has a biological role other than the apoptosis-inducing effects in CRC patients. The gene discussed is FOXO3; the disease is colorectal carcinoma.