In this study, we modeled the different biomarkers concerning pathological PTMs in Tau polypeptide in the hippocampal and entorhinal cortex regions of the brain using a DL and Transfer Learning pipeline that classifies AD and PSP tauopathies on IPMB images, provided by the National Biobank of Dementias of the National Autonomous University of Mexico (UNAM). The gene discussed is MAPT; the disease is supranuclear palsy, progressive, 1.