PLAT and intracranial hemorrhage: In the Seattle II trial, with a population of 149 patients with submassive or massive PE, a slightly higher dose of t-PA (24 mg) was used, resulting in a 10% major bleeding rate, absence of intracranial hemorrhage, a 42% reduction in RV/LV ratios, and a decrease in pulmonary arterial pressure by 29% from baseline to 48 h post-procedure (Table 8) [13].