In this study, the Mg2+ concentration that promotes HIF-1α expression also promotes MMP13 expression, although the mechanism remains to be further studied, this problem can be solved by trying to combine drugs such as zinc-binding and non-zinc-binding selective MMP-13 inhibitors that can inhibit MMP-13 expression in the treatment of osteoarthritis. The gene discussed is MMP13; the disease is osteoarthritis.