TSP-1 is known to bind integrins, Low Density Lipoprotein Receptor Related Protein-1 (LRP1), EGFR, TGF-beta, urokinase-type Plasminogen Activator (uPA), and VEGF-A, all of which are expressed on, or bind to, cancer cells (GEMICCL). This evidence concerns the gene THBS1 and cancer.