Interestingly, the anti-EGFR and anti-PEG bispecific Ab, that is, PEG engagerEGFR, bound both PEGylated liposomes containing doxorubicin (Doxisome) and EGFRs and showed antiproliferation activity in in vitro assay using EGFR-positive cancer cells [42]. Here, EGFR is linked to cancer.