We hypothesize that generation of CXCL4-specific antibodies, which are heparin independent, can be due to formation of complexes between CXCL4 and nucleic acids, as in SSc there is a high expression of CXCL4 and circulating and tissue-deposited CXCL4-DNA complexes [5]. Here, PF4 is linked to systemic sclerosis.