Indeed, we found no correlation between anti-CXCL4 antibodies and TNF-α, a cytokine also involved in SSc [19], and expressed in plasma of SSc patients, which reinforces the role of CXCL4 itself and anti-CXCL4 antibodies in participating, in particular, to sustain an IFN-I signature [11,12]. Here, TNF is linked to systemic sclerosis.