This work demonstrates that several targets, including AKT1, MAPK1, STAT3 and c-JUN, as well as several signalling pathways, including cGMP-PKG, AGE-RAGE, HIF-1, PI3K/AKT, JAK/STAT3 and JNK, are involved in the mechanism of Dan-Shen Decoction against IHD. Here, STAT3 is linked to myocardial ischemia.