CDKN2B-AS1, also referred to as ANRIL, is a long non-coding RNA (lncRNA) that downregulates CDKN2B expression when transcribed, through cis-acting heterochromatin formation.18,19ANRIL has been previously reported as a major GWAS hotspot,20 with multiple associations reported for cardiovascular phenotypes21,22 and neoplasms,23 including glioma.24CDKN2A encodes p16(INK4a) and p14(ARF); these gene products are translated from different reading frames of the CDKN2A gene and are therefore distinct proteins and not isoforms of one another. This evidence concerns the gene CDKN2A and central nervous system cancer.