Several observations argue for the presence of Neat1 in the cytoplasm: our FISH experiments clearly identify the Neat1-2 isoform in the cytoplasm (Figure 1—figure supplement 2), while a recent report shows that Neat1-1 isoform is released from nucleus to cytoplasm where it suppresses the Wnt signaling in leukemia stem cells and acts as a tumor suppressor in acute myeloid leukemia (Yan et al., 2021). The gene discussed is NEAT1; the disease is leukemia.