In the present study, the methylation status of EZH2 was lower in BLCA, UCEC, LUAD, LUSC, PRAD, READ, TGCT, and THCA than in normal tissues, and expression of EZH2 was up-regulated in these cancers, indicating that high expression of EZH2 might be caused by DNA methylation. Here, EZH2 is linked to cancer.