EZH2 and breast carcinoma: Compared with normal breast tissues, the protein expression levels of EZH2 were dramatically up-regulated in pancreatic adenocarcinoma (PAAD), head and neck squamous cell carcinoma (HNSC), lung adenocarcinoma (LUAD), UCEC, LIHC, and GBM, while the expression of EZH2 was significantly lower in breast cancer specimens (Figure 5B).