There was also no evidence that a low recent or nadir CD4+ T-cell count was associated with lower wild-type-specific or BA.1-specific ACE2 displacement activities 6 months post-third dose in COVID-19-naïve PWH (in fact, we observed a weak inverse relationship between nadir CD4+ T-cell count and Omicron BA.1-specific ACE2 displacement at this time; Supplementary Figure 1). This evidence concerns the gene ACE2 and COVID-19.