Since AML cells could attenuate anti‐tumor ability of immune cells,48 and high expression of immune checkpoint in the bone marrow leukemia cells correlated with poor prognosis,49 and our GO enrichment analysis of bulk RNA‐seq showed that upregulated genes in the Tim‐3high group were enriched in immune response and cytokine binding et al., we speculate that Tim‐3 has a dual role in AML (a): Tim‐3 expressed in LSC promotes leukemogenesis. The gene discussed is HAVCR2; the disease is neoplasm.