AKR1C3 and acute myeloid leukemia: With the Acute Myeloid Leukemia (TCGA, NEJM 2013) dataset (data_RNA_Seq_v2_mRNA_median_all_sample_Zscores.txt), we found that among those 16 stemness genes (one gene named SMIM24 wasn't tested in this cohort), AKR1C3 (p = 0.046), CD34 (P = 0.0058), and MMRN1 (P = 0.0063) were highly expressed in the Tim‐3high group (Figure 3C‐E) (the data were normalized with R package limma), and the rest genes were not significant difference(p > 0.05) (Figure S1).