IL18 and acute kidney injury: A study by Lin et al. in 2012 showed that urine IL-18 levels in pediatric patients (<18 years) and early AKI predictive time (12 h) were more effective in predicting AKI, with diagnostic odds ratios of 7.51 (2.99–18.88) and 8.18 (2.19–30.51), respectively (34).