Urine IL-18 biomarker (cut-off pint 3.868 ng/ml) detects the occurrence of AKI in septic patients on the first day of treatment in the PICU better than urine KIM-1 (cut-off point 1.666 ng/ml) and urinary IGFBP-7 (cut-off point 0.906 ng/ml). Here, HAVCR1 is linked to acute kidney injury.