Because of the high incidence of AKI due to sepsis, the difficulty in making a diagnosis, and the poor impact that arises from late diagnosis, it is essential to conduct a study to determine the role of urinary KIM-1, IL-18, and IGFBP-7 biomarkers in predicting the AKI occurrence in children with sepsis. The gene discussed is IGFBP7; the disease is acute kidney injury.