This interpretation is consistent with other threshold effects that have been seen in induced glaucoma models (Tao et al., 2019, 2020a) as well as the differential effects of acute (HIF-1α related) and chronic (HIF-2α related) hypoxia on cellular injury (Tezel and Wax, 2004; Mowat et al., 2010). The gene discussed is HIF1A; the disease is glaucoma.