However, endothelial damage in the blood–neuron interface, retrograde axonal transmission, infected leukocyte‐mediated transportation (Trojan horse), cytokine storming, immune complex‐mediated reactions, angiotensin‐converting enzyme‐2 (ACE‐2) mediated virus invasion, and thrombotic microangiopathy are the most accepted theories.13, 14, 15. This evidence concerns the gene ACE2 and thrombotic microangiopathy.