Roma et al. reported that HMB‐45 and melanocytic marker Melan‐A were sensitive markers for AML positivity 95% and 85% of the time, respectively, that 5% of AMLs were negative for HMB‐45 and positive for Melan‐A, and that combined staining with HMB‐45 and Melan‐A was positive in 100% of AMLs.9 Here, PMEL is linked to acute myeloid leukemia.