Interleukin IL-6 and IL-8 are confirmed to promote angiogenesis in tumor tissues, and treatment of tumor-bearing mice using EGCG suppressed the expression of IL-6 and IL-8 in a concentration-dependent manner, suggesting that IL-6 and IL-8 might mediate the anti-metastatic activity of EGCG (122). Here, CXCL8 is linked to neoplasm.