The combination of Sulindac and green tea catechins upregulated RARα1, but downregulated MAP3KI4 (NF-κB induced kinase), death-related protein kinase I (DAPK1), and tyrosine protein kinase (SKY), inhibiting the NF-κB pathway and blocking important signaling in cancer development, though GADD153, a key transcription factor inducing apoptosis, and P21, a protein blocking cell cycle and inhibiting proliferation, were not significantly upregulated when the two drugs were used individually (195). This evidence concerns the gene CDKN1A and cancer.