JUN and breast cancer: GTPs inhibited the uPA secretion and suppressed the metastatic behavior of BC cell malondialdehyde (MDA)-MB-231 by inhibiting activator protein-1 (AP-1) and nuclear factor κB (NF-κB) (110), in which an EGCG derivative 3e was able to inhibit the expression of both uPA and PAI-1, resulting in inhibition of the cancer cell metastasis (111).