The CAH diagnosis is based on biochemical findings; an elevated basal serum 17-hydroxyprogesterone (17OHP) is obligate in untreated classic forms of CAH, while in NC CAH, basal serum 17OHP is sometimes not elevated, so to exclude or confirm NC CAH stimulated 17OHP [with an adrenocorticotropic hormone (ACTH)-stimulation test] is required (15, 20, 23). Here, POMC is linked to congenital adrenal hyperplasia.